NoScript actually partially supports operation by the keyboard

That is, the new NoScript version after Firefox ESR.

A single left click is needed, but then the rest can be done using the keyboard! The left click can also be done by a macro keyboard so mouse is only used for cursor positioning.

The first domain will be selected (indicated by a light red outline). Another domain can be selected with arrow keys up and down.

Use arrow left to select an option, often “temp trusted”. The first press of arrow left will be confusing, because the option “CUSTOM” will expand (if the current setting is “DEFAULT”, then arrow left will wrap around the “CUSTOM”), but just keep going left. For most domains it will be three times arrow key left to select “temp trusted”.